This panel discussion, presented at the EPRI 2nd Annual Mind the Gap: Identifying Solutions for Electrolytic Hydrogen Production in March 2025, explores the critical role of safety and asset reliability in hydrogen electrolysis. The presentation highlights the importance of applying proven process safety management (PSM) frameworks to hydrogen operations, drawing on decades of industry experience to prevent incidents and enhance reliability. It examines the global network of regulations, engineering standards, and best practices for hydrogen safety, emphasizing the need for a consistent industry-wide approach to voluntary PSM to address gaps in regulatory coverage and ensure safe operations across the hydrogen value chain.